Drugs That Control Genes May Treat Lung Cancer
Researchers Report Some Success Against Advanced Lung Cancer With Epigenetic Drugs A new approach to treating cancer appears to help certain patients with advanced lung cancer, and researchers say they think they may have a way of spotting those who will benefit. The small study is generating big excitement in the world of cancer treatment because it demonstrates that so-called epigenetic drugs may work when traditional chemotherapy has failed. Epigenetic drugs work by controlling gene expression -- the way information from genes is used to create products such as proteins. The study is published in Cancer Discovery . "This is a ... groundbreaking study, showing that by modifying the epigenetics of a cancer cell we can get real responses in lung cancer," said Jeffrey A. Engleman, MD, PhD, director of thoracic oncology at Massachusetts General Hospital, in Boston, in a news briefing. "And getting real responses in lung cancer is actually quite dif