Painkillers Linked to Heart Rhythm Disorder
Study Suggests NSAIDs, Cox-2 Inhibitors May Raise Risk of Atrial Fibrillation Widely used anti-inflammatory pain relievers may increase the risk of atrial fibrillation, a common heart rhythm disorder associated with stroke and heart failure. In a newly published study from Denmark, use of non-selective, nonsteroidal anti-inflammatory drugs (NSAIDs) and Cox-2 inhibitors was associated with a significantly increased risk for atrial fibrillation. Non-selective NSAIDs include the active ingredients in drugs such as Advil, Motrin and Aleve, and Naprosyn. The prescription drug Celebrex is a Cox-2 inhibitor. The researchers also included older Cox-2 inhibitor drugs such as diclofenac (Voltaren), etodolac (Lodine), and meloxicam (Mobic). The risk was highest for new users of the drugs. New NSAID users had a 46% increase in risk, and new Cox-2 inhibitor users had a 71% increase in risk compared to people who did not take the pain relievers. WebMD contacted Pfizer -- the m